Update of the researches on the niche for spermatogonial stem cells.
- Author:
Lin HOU
1
;
Bing YAO
Author Information
1. PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Carrier Proteins;
metabolism;
Glial Cell Line-Derived Neurotrophic Factor;
metabolism;
Male;
Mice;
RNA-Binding Proteins;
Spermatogonia;
cytology;
metabolism;
Stem Cells;
cytology;
metabolism;
Testis;
cytology;
metabolism
- From:
National Journal of Andrology
2007;13(11):1028-1031
- CountryChina
- Language:Chinese
-
Abstract:
Spermatogonial stem cells are a population of immortal cells, capable of self-renewal and multi-directional differentiation. The theory of the "stem cell niche" was originally proposed for the hematopoietic system, and niches also exist in testicular tissues. The niche for spermatogonial stem cells is a semi-isolation system, characteristic of specific number regulation and changing with the age. The self-renewal of spermatogonial stem cells is regulated by two endogenous factors, nanos2 and Plzf, as well as by the niche cell-excreted factor, glial-derived neurotrophic factor (GDNF).
