Clinical significance and relevant laboratory techniques of detecting azoospermia factors of the Y chromosome.
- Author:
Wei-Ping WANG
1
;
Ying-Xia CUI
Author Information
1. PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing, Jiangsu 210002, China.
- Publication Type:Journal Article
- MeSH:
Azoospermia;
diagnosis;
genetics;
Chromosome Deletion;
Chromosomes, Human, Y;
genetics;
Genetic Loci;
Humans;
Infertility, Male;
diagnosis;
genetics;
Male;
Seminal Plasma Proteins;
genetics;
Sex Chromosome Aberrations
- From:
National Journal of Andrology
2007;13(12):1117-1120
- CountryChina
- Language:Chinese
-
Abstract:
Microdeletions of the Y chromosome are a most common known genetic cause of spermatogenetic failure in infertile men. Recent studies have revealed the existence of genetic factors in the long arm of the Y chromosome Yq11.23, known as azoospermia factors (AZF), which are further divided into three separate regions including AZFa, AZFb and AZFc. The AZF deletions are due to different recombination between large palindromic sequences during mesophase. Microdeletions of different AZF regions cause different degrees of spermatogenic impairment. The present paper reviews the clinical significance and relevant laboratory techniques of detecting AZF of the Y chromosome.
