Anti-apoptotic effect of the androgen receptor in human prostate cancer.
- Author:
Fang-Yun SHEN
1
;
Ben-Yi LI
Author Information
1. Department of Urology, Shenzhen Sun Hospital of Dalian Medical University, Shenzhen, Guangdong 518000, China. shenfangyun@hotmail.com
- Publication Type:Journal Article
- MeSH:
Apoptosis;
physiology;
Gene Expression Regulation, Neoplastic;
Humans;
Male;
Prostatic Neoplasms;
genetics;
pathology;
physiopathology;
RNA Interference;
Receptors, Androgen;
genetics;
physiology
- From:
National Journal of Andrology
2007;13(12):1121-1124
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is one of the common cancers in old men. Androgen ablation is a major option for the treatment of the metastatic diseases. However, most of the cancers progress to a more aggressive stage, so-called androgen-independent (or hormone refractory) relapse beyond any cure. The androgen receptor (AR) is an important factor in regulating the differentiation and proliferation of prostate epithelial cells, and also plays a critical role in cellular survival. Studies have demonstrated that aberrant activation of the AR is a major determinant in prostate cancer progression. We have provide a brief summary of AR-mediated cellular survival and an introduction to the advances of RNA interference techniques in silencing AR expression as a novel therapy for prostate cancer.
