Expression of apoptosis inhibitor gene Livin in prostate cancer and its clinical implication.
- Author:
Tao SONG
1
;
Bao-Fa HONG
;
Jiang-Ping GAO
;
Lei ZHANG
;
Wei CAI
Author Information
- Publication Type:Journal Article
- MeSH: Adaptor Proteins, Signal Transducing; biosynthesis; genetics; Aged; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Inhibitor of Apoptosis Proteins; biosynthesis; genetics; Male; Middle Aged; Neoplasm Proteins; biosynthesis; genetics; Neoplasm Staging; Prognosis; Prostatic Neoplasms; genetics; metabolism; pathology; Reverse Transcriptase Polymerase Chain Reaction
- From: National Journal of Andrology 2008;14(1):30-33
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of Livin, an apoptosis inhibitor gene, in prostate cancer, and to investigate its clinical and pathological implications.
METHODSThe expressions of Livin were detected in 62 cases of neoplastic prostate tissues and 10 cases of normal prostate tissues by RT-PCR and immunohistochemistry (SP method).
RESULTSThe Livin gene was highly expressed in neoplastic prostate tissues, but not in normal ones. Positive expression of Livin proteins was observed in 37 of the 62 (59.7%) tumor samples and accounted for 28.6%, 60.0% and 83.3% in the high, middle and low differentiation prostatic carcinoma groups respectively, with significant difference between the high and low groups. Livin positivity was also significantly correlated with tumor stages, increasing with tumor progression.
CONCLUSIONLivin may play an essential role in prostate carcinogenesis and serve as a marker for the prognosis of prostate cancer.
