Association between Alzheimer's disease and nitric oxide synthase III polymorphism.
- Author:
Qing-hua WANG
1
;
Jun-wu ZHANG
;
Zhen-xin ZHANG
;
Cheng-bin WU
;
Deng CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; enzymology; genetics; Female; Genotype; Humans; Male; Middle Aged; Nitric Oxide Synthase; genetics; metabolism; Polymorphism, Restriction Fragment Length
- From: Acta Academiae Medicinae Sinicae 2004;26(2):112-115
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association between Alzheimer's disease (AD) and nitric oxide synthase (NOS) III in Chinese Han population.
METHODSSeventy-five AD and 68 normal controls were genotyped for NOS III G894T polymorphism. Genotyping was carried out by PCR-RFLP methods.
RESULTSThere were two genotypes of NOS III, GG and GT, in either AD patients or normal controls. The frequencies of these two genotypes were 78.7% and 21.3% in AD patients and 82.4% and 17.6% in normal controls, respectively. No association was found between AD and NOS III genotype (P > 0.05). There were two alleles, G and T, in AD patients and normal controls. The frequencies of these two alleles were 89.3% and 10.7% in AD patients and 91.2% and 8.8% in normal controls, respectively, indicating that there was no association between AD and NOS III allels (P > 0.05).
CONCLUSIONSThere was no association between AD and NOS III G894T polymorphism in Chinese Han population.
