Synthesis and antioxiactivity of squamosamide cyclic analogs.
- Author:
Ping XIE
1
;
Xiao-zhen JIAO
;
Xiao-tian LIANG
;
Wei-hong FENG
;
Huai-ling WEI
;
Geng-tao LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Annonaceae; chemistry; Antioxidants; chemical synthesis; chemistry; pharmacology; Benzeneacetamides; chemical synthesis; chemistry; pharmacology; Phenols; chemical synthesis; chemistry; pharmacology; Rats
- From: Acta Academiae Medicinae Sinicae 2004;26(4):372-378
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo design and synthesize a series of squamosamide cyclic analogues and to test their antioxidation activity.
METHODSEleven 3-substituted indole-2-one derivatives were designed and synthesized through 9 steps with p-hydroxyphenylacetic acid as the starting material and their structures were confirmed by nuclear magnetic resonance and mass spectrometry.
RESULTSEleven compounds showed antioxidation activity and the activities of compounds 9 and 13 matches the positive control FLZ-52.
CONCLUSIONCyclic reconstruction with FLZ-52 as the lead compound have some antioxidation activity.
