Distribution of tetracycline-arginine-glycine-aspartate-tyrosine in mice and its effect on bone.
- Author:
Chen-lin DAI
1
;
Xiao-ying DING
;
Xin ZHANG
;
Kun-ming CHEN
;
Mo-ling ZHANG
;
Ming-cai QIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Density; drug effects; Bone Remodeling; drug effects; Female; Mice; Oligopeptides; pharmacokinetics; pharmacology; Osteoporosis; metabolism; prevention & control; Ovariectomy; Rats; Rats, Sprague-Dawley; Tetracycline; pharmacokinetics; pharmacology; Tissue Distribution; Tyrosine; pharmacokinetics; pharmacology
- From: Acta Academiae Medicinae Sinicae 2004;26(4):399-404
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of tetracycline-arginine-glycine-aspartate-tyrosine (T-RGDY) in mice and its effect on bone.
METHODS125-labeled T-RGDY was studied for its distribution in mice and for its effects on bone by histomorphometry in ovariectomized rats.
RESULTSThe 125I-labeled T-RGDY was more concentrated in the osteoporotic bone than in the normal bone. Compared with ovariectomy group, the morphologic index such as trabecular bone volume/total tissue volume (TBV/TTV), TBV/sponge bone volume (SBV), and mean trabecular plate thickness (MTPT) in T-RGDY group significantly increased (P < 0.05). As compared with sham operation group, MTPT significantly increased in T-RGDY group (P < 0.05), while TBV/SBV and mean trabecular plate density significantly decreased (P < 0.05), and TBV/TYV and mean trabecular plate spacing were almost the same as those in sham operation group (P > 0.05).
CONCLUSIONT-RGDY may concentrate in bone tissue to a certain degree, which is closely related with the status of bone remodeling. T-RGDY may inhibit the bone loss caused by ovariectomy.
