Advance in synthesis of ketolides, a new class of erythromycin derivatives.
- Author:
Ping-sheng LEI
1
;
Peng XU
;
Lu LIU
Author Information
1. Department of New Drug Development, Institute of Materia Medica, CAMS and PUMC, Beijing 100050, China. lei@imm.ac.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Anti-Bacterial Agents;
chemical synthesis;
chemistry;
pharmacology;
Drug Resistance, Bacterial;
Erythromycin;
analogs & derivatives;
chemical synthesis;
pharmacology;
Humans;
Ketolides;
chemical synthesis;
chemistry;
pharmacology;
Macrolides;
chemical synthesis
- From:
Acta Academiae Medicinae Sinicae
2004;26(4):467-473
- CountryChina
- Language:Chinese
-
Abstract:
Drug-resistance has become a challenging clinical problem. Ketolides, a new class of erythromycin derivatives, have shown promising effectiveness in killing drug-resistant bacteria. This article reviews recent development in synthesis of ketolides, with focus on the modification and synthesis of some important positions on erythromycin A cycles.
