Long-term immunogenicity of the influenza vaccine at reduced intradermal and full intramuscular doses among healthy young adults.
10.7774/cevr.2013.2.2.115
- Author:
Joon Young SONG
1
;
Hee Jin CHEONG
;
Ji Yun NOH
;
Tae Un YANG
;
Yu Bin SEO
;
Kyung Wook HONG
;
In Seon KIM
;
Won Suk CHOI
;
Woo Joo KIM
Author Information
1. Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. heejinmd@medimail.co.kr
- Publication Type:Original Article
- Keywords:
Vaccines;
Influenza vaccines;
Immunogenicity;
Intradermal injections;
Adult
- MeSH:
Adult;
Antibody Formation;
Hemagglutination;
Hemagglutinins;
Humans;
Influenza Vaccines;
Influenza, Human;
Injections, Intradermal;
Pandemics;
Vaccination;
Vaccines;
Young Adult
- From:Clinical and Experimental Vaccine Research
2013;2(2):115-119
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To prepare for vaccine shortages under an influenza pandemic, several antigen-sparing strategies have been investigated. This study was aimed to evaluate the immunogenicity of influenza vaccine at reduced intradermal and full intramuscular dose. MATERIALS AND METHODS: We compared the effect of one-fifth and one-half intradermal doses to the full intramuscular dose on immunogenicity in healthy young adults, using a commercial influenza vaccine. A hemagglutination inhibition assay was used to compare the immunogenicity of the vaccination methods. RESULTS: The one-fifth intradermal dose (3 microg hemagglutinin antigen, HA) was given to 30 participants, the one-half intradermal dose (7.5 microg HA) was given to 30, and the full intramuscular dose (15 microg HA) was given to 32. No significant differences among injection routes and dosages were seen for seroprotection rate, seroconversion rate, or geometric mean titer (GMT) fold-increase for A/H1N1, A/H3N2, and B at around 4 weeks from vaccination. Although GMT for influenza B was significantly lower at six months for the one-fifth intradermal vaccination compared to the full-dose intramuscular vaccination (32.8 vs. 63.2, p=0.048), all three groups met the Evaluation of Medicinal Products (EMA) immunogenicity criteria through 1 to 6 months. CONCLUSION: Intradermal administration of a one-fifth dose of influenza vaccine elicited antibody responses comparable to the intradermal one-half dose and a conventional intramuscular vaccination at 1 month post-vaccination. The immunogenicity of the one-fifth intradermal dose was sufficient to meet the requirement for the EMA criteria at six months after influenza vaccination.
