Correlation of Lower Concentrations of Hydrogen Sulfide with Activation of Protein Kinase CβII in Uremic Accelerated Atherosclerosis Patients.
- Author:
Wei WANG
;
Su-Juan FENG
;
Han LI
1
;
Xiao-Dong ZHANG
;
Shi-Xiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Atherosclerosis; blood; enzymology; metabolism; Blotting, Western; Humans; Hydrogen Sulfide; blood; Middle Aged; Protein Kinase C; metabolism; Renal Dialysis; Young Adult
- From: Chinese Medical Journal 2015;128(11):1465-1470
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDHydrogen sulfide (H 2 S) plays a protective role in chronic hemodialysis (CHD) patients. In this study, we further investigate the relationship between H 2 S and conventional protein kinase CβII (cPKCβII) in CHD patients with uremic accelerated atherosclerosis (UAAS).
METHODSA total of 30 healthy people, 30 CHD patients without AS and 30 CHD patients with AS (CHD + AS) were studied. Plasma H 2 S was measured with a sulfide sensitive electrode, and cPKCβII membrane translocation was detected by Western blotting.
RESULTSPlasma H 2 S in CHD + AS group was significantly lower than that in CHD patients. cPKCβII membrane translocation in CHD + AS group increased significantly compared with CHD group. Plasma H 2 S concentration was negatively correlated with cPKCβII membrane translocation in CHD + AS patients.
CONCLUSIONSThese findings suggest a possible linkage between H 2 S metabolism and cPKCβII activation, which may contribute to the development of UAAS in CHD patients.
