Variants of Interferon Regulatory Factor 5 are Associated with Neither Neuromyelitis Optica Nor Multiple Sclerosis in the Southeastern Han Chinese Population.
- Author:
Qi-Bing LIU
;
Lei WU
;
Gui-Xian ZHAO
;
Ping-Ping CAI
;
Zhen-Xin LI
;
Zhi-Ying WU
1
;
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; genetics; China; Female; Genetic Predisposition to Disease; genetics; Genotype; Humans; Interferon Regulatory Factors; genetics; Male; Middle Aged; Multiple Sclerosis; genetics; Neuromyelitis Optica; genetics; Polymorphism, Single Nucleotide; genetics
- From: Chinese Medical Journal 2015;128(13):1743-1747
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDNeuromyelitis optica (NMO) and multiple sclerosis (MS) are demyelinating disorders of the central nervous system. Interferon regulatory factor 5 (IRF5) is a common susceptibility gene to different autoimmune disorders. However, the association of IRF5 variants with NMO and MS patients has not been well studied. Therefore, we aimed to evaluate whether IRF5 variants were associated with NMO and MS in the Southeastern Han Chinese population.
METHODSFour single nucleotide polymorphisms (SNPs) were selected and genotyped by matrix-assisted laser desorption/ionization time of flight mass spectrometry in 111 NMO patients, 145 MS patients and 300 controls from Southeastern China.
RESULTSNone of these 4 SNPs was associated with NMO or MS patients.
CONCLUSIONSOur preliminary study indicates that genetic variants in IRF5 may affect neither NMO nor MS in the Southeastern Han Chinese population. Further studies with a large sample size and diverse ancestry populations are needed to clarify this issue.
