Effect of sijunzi decoction on the intestinal glucose absorption in model rats of Pi-qi deficiency syndrome: an experimental research.
- Author:
Jia LIU
1
;
Wen-Feng GUO
1
;
Li REN
1
;
Wei-Wen CHEN
1
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; pharmacology; Female; Glucose; metabolism; Glucose Transporter Type 2; metabolism; Intestinal Absorption; drug effects; Intestinal Mucosa; drug effects; metabolism; Intestine, Small; drug effects; metabolism; Qi; Rats; Rats, Sprague-Dawley; Reserpine; adverse effects
- From: Chinese Journal of Integrated Traditional and Western Medicine 2013;33(10):1389-1393
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Sijunzi Decoction (SD) on the intestinal absorption of glucose in model rats of Pi-qi deficiency syndrome (PQDS).
METHODSPQDS rat model was established by subcutaneous injection of reserpine from the neck. The body weight and urine D-xylose excretion rates were measured. The glucose uptake rate was measured by jejunum perfusion. The intestinal mucosa was collected. The glucose transporter-2 (GLUT2) protein and mRNA expression levels were detected.
RESULTSCompared with the normal control group, the body weight and D-xylose excretion rates decreased in the model group. Meanwhile, the glucose uptake and GLUT2 protein and mRNA expression levels decreased in the model group. The aforesaid indices were improved in the SD group.
CONCLUSIONSD could promote the recovery of glucose uptake in the small intestine of reserpine induced PQDS rats.
