Treating influenza patients of wind-heat affecting Fei syndrome by jinhua qinggan granule: a double-blinded randomized control trial.

Guo-qin LI; Jing Zhao; Zhi-tao TU; Jiang-bin LI; Qing-quan Liu; Li-qing Shi; Qing Miao; Hui-qing Yuan; Xin-qiao Liu; You-yu Long; Zhi-guo Liu; Ting Zhao; Lei LI; Quan-hong Tant; Ying-chun HE; Yong-jun Bian; Jing-qing HU

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Treating influenza patients of wind-heat affecting Fei syndrome by jinhua qinggan granule: a double-blinded randomized control trial.

Author: Guo-Qin LI ¹ ; Jing ZHAO ² ; Zhi-Tao TU ² ; Jiang-Bin LI ² ; Qing-Quan LIU ² ; Li-Qing SHI ³ ; Qing MIAO ⁴ ; Hui-Qing YUAN ⁵ ; Xin-Qiao LIU ⁶ ; You-Yu LONG ⁷ ; Zhi-Guo LIU ¹ ; Ting ZHAO ¹ ; Lei LI ¹ ; Quan-Hong TANT ⁸ ; Ying-Chun HE ⁹ ; Yong-Jun BIAN ¹ ; Jing-Qing HU ¹
Author Information

1. Respiratory Department, Guang'anmen Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing 100053, China.
2. Emergency Department, Dongzhimen Hospital Affiliated to Bejing University of Chinese Medicine, Beijing 100700, China.
3. Respiratory Department, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China.
4. Respiratory Department, Xiyuan Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing 100091, China.
5. Respiratory Department, Beijing Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing 100010, China.
6. Respiratory Department, First Hospital Affiliated to Tianjin University of Tradi tional Chinese Medicine, Tianjin 300193, China.
7. Respiratory Department, Second Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300151, China.
8. Beijing Supertrack Medical Technology Development Co., Ltd., Beijing 100029, China.
9. Clinical Medicine Research Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Publication Type:Journal Article
MeSH: Adult; Double-Blind Method; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Influenza, Human; diagnosis; drug therapy; Male; Medicine, Chinese Traditional; Phytotherapy; Young Adult
From: Chinese Journal of Integrated Traditional and Western Medicine 2013;33(12):1631-1635
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo assess the effect and safety of Jinhua Qinggan Granule (JHG) in treating influenza patients of wind-heat affecting Fei syndrome (WHAFS).
METHODSTotally 136 influenza patients of WHAFS were randomized by stratification into 3 groups, the high dose JHG group (44 cases, 10 g each time), the low dose JHG group (45 cases, 5 g JHG + 5 g placebo each time), and the placebo control group (47 cases, 10 g placebo each time). All medication was administered three times daily for 5 days. The fever disappearance time, the fever disappearance rate, efficacy of TCM syndrome, the disappearance rate of main symptoms and physical signs of flu, the negative rate of virus nucleic acid in the pharyngeal secretion, and safety indicators were assessed.
RESULTSThe median fever disappearance time was 32.8 h (95% CI: 22.5-41.0 h) in the high dose JHG group, 26.0 h (95% CI: 14.5-36.5 h) in the low dose JHG group, 39.5 h (95% CI: 29.0-46.0 h) in the placebo control group. There was statistical difference in the median fever disappearance time between the low dose JHG group and the placebo control group (P = 0.011). Three days after treatment, the markedly effective rate of TCM symptoms in the low dose JHG group was 66.7%, higher than that of the placebo control group (38.3%), and its effective rate was superior to that of the high dose JHG group (P = 0.043). Five days after treatment, the recovery rate of the low dose JHG group (42.2%) was higher than that of the high dose JHG group (25.0%, P = 0.026) and that of the placebo control group (14.9%, P = 0.002). The markedly effective rate of the low dose JHG group (86.7%) was higher than that of the placebo control group (55.3%, P = 0.001). Similar effects were obtained in the low dose JHG group and the high dose JHG group, but slightly poor in partial indicators of the high dose JHG group. There was no statistical difference in adverse reaction among these three groups (P > 0.05).
CONCLUSIONSJHG was effective and safe in treating influenza patients of WHAFS. Routinely low dose was the optimal dosage of JHG.