Effects of yougui drink on the osteogenic differentiation of mesenchymal stem cells in the proximal femur in steroid-induced avascular necrosis of femoral head.
- Author:
Yun-gang WU
1
;
Lu-wei XIAO
;
Pei-jian TONG
Author Information
- Publication Type:Journal Article
- MeSH: Cell Differentiation; Cell Proliferation; drug effects; Cells, Cultured; Drugs, Chinese Herbal; chemistry; pharmacology; Female; Femur Head Necrosis; drug therapy; physiopathology; Humans; Male; Mesenchymal Stromal Cells; cytology; drug effects; Middle Aged; Osteoblasts; cytology; drug effects; Osteonecrosis; Steroids; pharmacology
- From: China Journal of Orthopaedics and Traumatology 2009;22(2):115-117
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Yougui drink on osteogenic differentiation of bone mesenchymal stem cells (BMSCs) in the proximal femur in steroid-induced avascular necrosis of femoral head in vitro.
METHODSThe BMSCs were induced to osteoblasts in vitro with a conditional medium. The cells cultured with Yougui drink serum were compared with the ordinary one, which both were examined by microscopy, MTU method, ALP and calcium node.
RESULTSMicroscopy and MTU studies showed that Yougui drink could improve proliferation of the osteoblasts. ALP and calcium node studies showed that Yougui drink could improve the activity of the osteoblasts (P < 0.01).
CONCLUSIONYougui drink has positive effects on osteogenic differentiation of mesenchymal stem cells in the proximal femur in steroid-induced avascular necrosis of femoral head in vitro.
