Change of cartilage matrix metabolism under stress.
- Author:
Yue-feng SHAO
1
;
Xiao-chun WEI
Author Information
1. Department of Orthopaedics, the Second Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi, China.
- Publication Type:Journal Article
- MeSH:
Cartilage;
metabolism;
Humans;
Matrix Metalloproteinases;
metabolism;
Osteoarthritis;
metabolism;
Stress, Mechanical;
Tissue Inhibitor of Metalloproteinases;
metabolism
- From:
China Journal of Orthopaedics and Traumatology
2009;22(3):241-244
- CountryChina
- Language:Chinese
-
Abstract:
With the effects of the mechanics and biological factors, the imbalance between the degradation and synthesis of chondrocyte, extracelluar matrix and subchondral bone leads to the osteoarthritis. The imbalance between MMPs and TIMPs caused by biomechanical abnormality is the key factor of osteoarthritis. This review will focus on the stress and their roles in the metabolism of the cartilage matrix.
