The mechanism and application of posttranscriptional gene silencing.
- Author:
Yang LIU
1
;
Yan JIANG
;
Dai-Rong QIAO
;
Yi CAO
Author Information
1. National Laboratory for Grassland Biotechnology, College of Life Science, Sichuan University, Chengdu 610064, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Gene Silencing;
Models, Genetic;
RNA;
RNA Processing, Post-Transcriptional
- From:
Chinese Journal of Biotechnology
2002;18(2):140-143
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this review is to confirm the reason resulted the gene silence and explore the countermeasure avoiding the gene silence in transgene plant. The method is to divide the gene silencing into transcriptional gene silencing(TGS) and posttranscriptional gene silencing(PTGS). Several models resulted PTGS were analyzed by RNA threshold model, ectopic pairing and aberrant RNA model and ds-RNA model. The results showed that it was important to decide the phenomena of restraining transgene silencing and the mechanism of PTGS. The strategies of identification of gene function and prevention of virus were presented by RNAi and gene silencing respectively, etc.
