Fluvastatin's effect on atherogenesis in apolipoprotein-E knockout mice infected by cytomegalovirus
10.3760/cma.j.issn.1003-9279.2010.06.013
- VernacularTitle:氟伐他汀对巨细胞病毒感染后载脂蛋白E基因敲除小鼠动脉硬化的影响
- Author:
Li YI
1
;
Jia-Wei WANG
;
Ri-Guang ZHAO
;
Hou-Zhen TUO
;
Zi-Jing FENG
;
De-Xin WANG
Author Information
1. 首都医科大学附属北京友谊医院
- Keywords:
Muromegalovirus;
Mice;
Arteriosclerosis;
Fluvastatin
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(6):433-435
- CountryChina
- Language:Chinese
-
Abstract:
Objective The goal of this study was to investigate whether murine cytomegalovirus (MCMV) is able to exacerbate the atherosclerotic process in apolipoprotein E knockout (apoE-/-) mice,and the effect of fluvastatin on the atherogenesis. Methods The apoE -/- mice kept on a west diet were given low dosage of MCMV. At 14,18 and 24 weeks post infection, AS lesion were measured on aorta. The fluvastatin was administered,and AS lesion were measured accordingly above. Results We observed that in the chronic phase of the infection, AS lesion area was significantly increased. MCMV gB mRNA was not amplified by real-time PCR from the arterial wall. The IgG antibody level of MCMV in blood plasma and the content of virus DNA in salivary gland were not correlated with AS lesions. After the administration of fluvastatin, there was no significant difference of AS lesions between MCMV infected group and mockinfected group. Conclusion MCMV may aggravate the AS lesion in apoE -/- mice in the chronic phase of infection, and promote more severe type of AS lesions. But it might not be the direct effects of mechanism of MCMV on the local lesion of AS. Fluvastatin could meliorate the progression of AS after MCMV infection,but this was not accomplished by decreasing MCMV duplication.
