The association between HBV genotyping and clinical characteristics and expression of TH1/TH2 cytokines.
- Author:
Si-Min YAO
1
;
Jing YUAN
;
Fan ZHANG
;
Xin-Chun CHEN
;
Ming-Xia ZHANG
;
Hong LIU
;
Ying-Xia LIU
;
Bin WEN
;
Ming WU
;
Wei DAI
;
Dong WANG
;
Bo-Ping ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Genotype; Hepatitis B virus; genetics; immunology; Hepatitis B, Chronic; immunology; virology; Humans; Interferon-gamma; biosynthesis; Interleukin-4; biosynthesis; Male; Th1 Cells; immunology; Th2 Cells; immunology
- From: Chinese Journal of Experimental and Clinical Virology 2010;24(6):439-441
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association between HBV genotyping and clinical characteristics and expression of TH1/TH2 cytokines.
METHODSThe expression of IL-4 and IFN-gamma was detected with flow cytometry for 102 HBV infections and 48 healthy controls. 50 CHB patients were randomly selected for HBV genotyping with real-time fluorescence PCR assay.
RESULTSHigher expression of IL-4 in peripheral blood was detected in patients with HBV infection than healthy controls (P < 0.001); No significant differences on expression of Th1/Th2 cytokines were observed in CHB patients with different HBV DNA levels or HBeAg status (P > 0.05). There were 34 (68%) patients with genotype B infection and 16 (32%) with genotype C infection. Compared to patients with genotype B infection, the patients with genotype C infection showed higher levels of IL-4 (P = 0.018), and Th1/Th2 ratio decreased,but the difference was not statistically significant (P = 0.2262).
CONCLUSIONThe different expression of TH1/TH2 cytokines may elucidate cellular immune response and clinical outcome difference between patients with genotype B infection and genotype C infection.
