The association between HBV genotyping and clinical characteristics and expression of TH1/TH2 cytokines
10.3760/cma.j.issn.1003-9279.2010.06.015
- VernacularTitle:乙型肝炎病毒基因分型与临床及TH1/TH2细胞因子相关性
- Author:
Si-Min YAO
1
;
Jing YUAN
;
Fan ZHANG
;
Xin-Chun CHEN
;
Ming-Xia ZHANG
;
Hong LIU
;
Ying-Xia LIU
;
Bin WEN
;
Ming WU
;
Wei DAI
;
Dong WANG
;
Bo-Ping ZHOU
Author Information
1. 广东医学院附属深圳市第三人民医院
- Keywords:
Hepatitis B virus;
Genotype;
Immunity,cellular
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(6):439-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between HBV genotyping and clinical characteristics and expression of TH1/TH2 cytokines. Methods The expression of IL-4 and IFN-γ was detected with flow cytometry for 102 HBV infections and 48 healthy controls. 50 CHB patients were randomly selected for HBV genotyping with real-time fluorescence PCR assay. Results Higher expression of IL-4 in peripheral blood was detected in patients with HBV infection than healthy controls ( P ＜ 0. 001 ); No significant differences on expression of Th1/Th2 cytokines were observed in CHB patients with different HBV DNA levels or HBeAg status(P ＞ 0.05). There were 34 (68%)patients with genotype B infection and 16 (32%) with genotype C infection. Compared to patients with genotype B infection,the patients with genotype C infection showed higher levels of IL-4( P = 0. 018 ), and Th1/Th2 ratio decreased, but the difference was not statistically significant( P = 0. 2262). Conclusion The different expression of TH 1/TH2 cytokines may elucidate cellular immune response and clinical outcome difference between patients with genotype B infection and genotype C infection.
