miR-196a-2 gene polymorphism and the antiviral therapy of chronic hepatitis C
10.3760/cma.j.issn.1003-9279.2010.06.025
- VernacularTitle:miR-196a-2基因多态性与慢性丙型肝炎抗病毒治疗疗效的关系
- Author:
Xiao-Lv HONG
1
;
Hong CAO
;
Fang ZHAO
;
Xing-Fei PAN
;
Ka ZHANG
;
Qi-Huan XU
;
Zhi-Xin ZHAO
;
Gang LI
Author Information
1. 中山大学附属第三医院
- Keywords:
RNA;
Genes;
Hepacivirus;
Alleles
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(6):470-472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the SNP rs11614913 on miR196a-2 gene and the treatment effects of Peg-IFN-α plus Ribavirin on chronic hepatitis C patients. Methods The total 139 patients of chronic hepatitis C infection who received the treatment of Peg-IFN-α-2a or Peg-IFN-α-2b plus Ribavirin were enrolled in this study. The patients were divided into two groups: sustained virological response(SVR) ( n = 82 ) group and non virological response ( NVR ) or recurrence ( n = 57 )group. Blood samples were collected and chromosomal DNA was extracted. The miR-196a-2 polymorphism was determined with the method of polymerase chain reaction (PCR)-restriction fragment length polymorphism(RFLP). Results In our study, there was statistically association between miR-196a-2polymorphism and the antiviral therapy efficacy of hepatitis C patients. There was statistically significance in the CT genotype and the TT genotype of m iR-196a-2 between the two groups [P = 0. 009, A = 2. 924( 1. 285-6. 652)]. There was statistically significance in the CC genotype and the TT genotype between the two groups [P = 0. 036, A = 3.091 ( 1. 052 - 9. 078 )]. There was statistically significance in the C allele and the T allele between the two groups [P =0.036, A =3.091(1.052 -9.078)]. Conclusion These findings suggested that the rs11614913 SNP in miR - 196a-2 be associated with the antiviral therapy efficacy of hepatitis C patients, and the TT genotype or T alleles be associated with the SVR while the CC genotype or C allele could be related to the NVR or recurrence.
