The relationship of serum HBsAg, HBeAg concentration and HBV-DNA load in chronic hepatitis B during IFN treatment.
- Author:
Ming-hui LI
1
;
Yao XIE
;
Guo-hua QIU
;
Yao LU
;
Hui ZHAO
;
Min YANG
;
Shu-jing SON
;
Feng LIU
;
Shu-feng ZHANG
;
Li-jun CHEN
;
Jun CHENG
;
Dao-zhen XU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; DNA, Viral; blood; Female; Hepatitis B Surface Antigens; blood; Hepatitis B e Antigens; blood; Hepatitis B, Chronic; drug therapy; virology; Humans; Interferon-alpha; therapeutic use; Male; Middle Aged; Viral Load
- From: Chinese Journal of Experimental and Clinical Virology 2011;25(1):26-28
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relation of serum HBsAg, HBeAg contents and HBV-DNA load changes in HBeAg-positive chronic hepatitis B during IFN-alpha treatment.
METHODSAfter enrolled, the patients were treated with 3MU-5MU IFN subcutaneous injection every two days, and their serum was collected before treatment and every 3 months during the treatment course. The serum HBV-DNA load was determined by real-time fluorescence quantitative PCR method kit (lower detection limit 500 copies/ml, Piji company, Shenzhen city, China,) according to production instruction, and HBeAg and HBsAg contents were detected by ARCHITECH I 2000.chemiluminescent kit. The relation of serum HBV-DNA, HBeAg and HBsAg content was analyzed by SPSS statistic software.
RESULTSThere were 228 patients enrolled into this group, male 162 cases, female 66 cases, aged 14-60 years, average 30.94 years old. After IFN treatment the HBV-DNA, HBeAg and HBsAg levels were all gradually decreased. But there was no relation of HBsAg content to HBV DNA and HBeAg content before and during treatment course(P > 0.05). However the serum HBeAg content was related to HBV-DNA content significantly (P < 0.05) and their changes was correspondence.
CONCLUSIONBefore and during treatment of interferon, HBeAg and HBV-DNA content changes are closely related, while there is no significant correlation between HBsAg and HBeAg and HBV-DNA content. During interferon therapy, HBsAg, HBeAg, HBV-DNA contents should be detected together.