The relationship of serum HBsAg, HBeAg concentration and HBV-DNA load in chronic hepatitis B during IFN treatment
10.3760/cma.j.issn.1003-9279.2011.01.010
- VernacularTitle:慢性乙型肝炎HBsAg,HBeAg和DNA变化的相关性研究
- Author:
Ming-Hui LI
1
;
Yao XIE
;
Guo-Hua QIU
;
Yao LU
;
Hui ZHAO
;
Min YANG
;
Shu-Jing SONG
;
Feng LIU
;
Shu-Feng ZHANG
;
Li-Jun CHEN
;
Jun CHENG
;
Dao-Zhen XU
Author Information
1. 首都医科大学附属北京地坛医院肝病中心
- Keywords:
Hepatitis B,chronic;
Treatment outcome;
Interferon-alpha;
Hepatitis B Surface antigens;
Hepatitis B e antigens;
DNA
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(1):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation of serum HBsAg, HBeAg contents and HBV-DNA load changes in HBeAg-positive chronic hepatitis B during IFN-α treatment. Methods After enrolled, the patients were treated with 3MU-5MU IFN subcutaneous injection every two days, and their serum was collected before treatment and every 3 months during the treatment course. The serum HBV-DNA load was determined by real-time fluorescence quantitative PCR method kit ( lower detection limit 500 copies/ml, Piji company, Shenzhen city, China,) according to production instruction, and HBeAg and HBsAg contents were detected by ARCHITECH I 2000.chemiluminescent kit. The relation of serum HBV-DNA, HBeAg and HBsAg content was analyzed by SPSS statistic software. Results There were 228 patients enrolled into this group, male 162 cases, female 66 cases, aged 14-60 years, average 30. 94 years old. After 1FN treatment the HBV-DNA, HBeAg and HBsAg levels were all gradually decreased. But there was no relation of HBsAg content to HBV DNA and HBeAg content before and during treatment course( P ＞0.05 ). However the serum HBeAg content was related to HBV-DNA content significantly (P ＜ 0.05 ) and their changes was correspondence. Conclusion Before and during treatment of interferon, HBeAg and HBV-DNA content changes are closely related, while there is no significant correlation between HBsAg and HBeAg and HBV-DNA content. During interferon therapy, HBsAg, HBeAg, HBV-DNA contents should be detected together.
