Study for association between high risk human papillomavirus and cervical lesions in the samples from opportunistic screening.
- Author:
Li-hua BIAN
1
;
Ying LI
;
Xiao-li WANG
;
Xiao-zhou WU
;
Lei SONG
;
Hong-tu LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alphapapillomavirus; classification; genetics; isolation & purification; Cervix Uteri; pathology; virology; China; epidemiology; Female; Humans; Middle Aged; Papillomavirus Infections; diagnosis; epidemiology; pathology; virology; Risk Factors; Uterine Cervical Diseases; diagnosis; epidemiology; pathology; virology; Vaginal Smears; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2011;25(2):89-91
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between HPV genotypes and cervical lesion in Hybrid Capture 2 (HC2) HPV test positive samples.
METHODS602 cervical samples randomly obtained detected as HPV positive by the HC2 high-risk probe cocktail were determined by polymerase chain reaction (PCR)-reverse dot blot (RDB), among them 344 participated Thinprep Cytology test.
RESULTS569 (94.5%) samples were successfully amplified. The most common HPV genotypes were HPV16 (31.6%), 52 (16.7%), 58 (15.1%), 56 (8.1%), 39 (7.9%); HPV16 or HPV16/18 infection was significantly related to ASCUS, LSIL and HSIL; 24 samples suggested single HPV infection with the genotypes not available for HC2.
CONCLUSIONThe most common HPV genotypes in random screening were HPV16, 52 and HPV58; Our data demonstrated the pseudo-positivity of HC2 test was 4.0%; HPV16 was a index for progression of HSIL.
