Bioinformatics analysis of the structure and function correlated to interferon sensitivity of HCV core protein.
- Author:
Ling CHENG
1
;
Yan GUO
;
Guo-hu HONG
;
Qing MAO
Author Information
- Publication Type:Journal Article
- MeSH: Amino Acid Sequence; Computational Biology; Hepacivirus; chemistry; drug effects; genetics; metabolism; Hepatitis C; drug therapy; virology; Humans; Interferons; therapeutic use; Molecular Sequence Data; Protein Conformation; Viral Core Proteins; chemistry; genetics; metabolism
- From:Chinese Journal of Experimental and Clinical Virology 2011;25(2):96-98
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze and predict the structure and function correlated to interferon sensitivity of HCV Core protein in different genotypes.
METHODSUsing different bioinformafics software respectively to comparatively analyze and predict the secondary structure, tertiary structure, modification site and main functional motifs of HCV Core protein.
RESULTSThere were diversities in secondary structure and tertiary structure of different genotypes. HCV Core protein would exist some modification sites about amidation, cAMP, PKC, TYR, and interact with amphiphysin SH3 domain, ERK, PKC.
CONCLUSIONDifferences in structure and function of HCV Core protein of different genotypes affected interferon sensitivity.
