Bioinformatics analysis of the structure and function correlated to interferon sensitivity of HCV Core protein
10.3760/cma.j.issn.1003-9279.2011.02.005
- VernacularTitle:HCV Core蛋白与IFN敏感性相关结构及功能的生物信息学分析
- Author:
Ling CHENG
1
;
Yan GUO
;
Guo-Hu HONG
;
Qing MAO
Author Information
1. 第三军医大学附属西南医院
- Keywords:
Hepatitis C;
Viral core proteins;
Bioinformatics analysis;
Genes,structure;
Interferons
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(2):96-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze and predict the structure and function correlated to interferon sensitivity of HCV Core protein in different genotypes. Methods Using different bioinformafics software respectively to comparatively analyze and predict the secondary structure, tertiary structure, modification site and main functional motifs of HCV Core protein. Results There were diversities in secondary structure and tertiary structure of different genotypes. HCV Core protein would exist some modification sites about amidation, cAMP, PKC, TYR, and interact with amphiphysin SH3 domain, ERK, PKC. Conclusion Differences in structure and function of HCV Core protein of different genotypes affected interferon sensitivity.
