One case of correlation between the human herpesvirus 7 DNA load and the hemo hagocytic syndrome.
- Author:
Peng CAI
1
;
Chun-rong TONG
;
Jun-fang YANG
;
Ying LIU
;
Guo-lin XU
;
Gian-feng ZHANG
;
Cheng-liang ZHEN
;
Gun-fang LI
;
Zhi-ping TENG
Author Information
- Publication Type:Case Reports
- MeSH: Ferritins; metabolism; Herpesvirus 7, Human; genetics; isolation & purification; physiology; Humans; Lymphohistiocytosis, Hemophagocytic; metabolism; virology; Viral Load
- From:Chinese Journal of Experimental and Clinical Virology 2011;25(2):123-125
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the relationship between human herpesvirus 7 (HHV-7) viral Load and the etiopathogenisis of hemophagocytic syndrome, in order to provide evidence for the clinical diagnosis of hemophagocytic syndrome and anti-virus therapy.
METHODSPeripheral blood of patient with hemophagocytic syndrome during different treatment periods, extracted DNA, Syntheticed the primers of HHV-7, gene sequence of PCR amplified fragments detected, determined HHV-7 viral Load by Real-time fluorescent quantitative PCR and the ferritin concentration in peripheral blood detected by chemiluminescence.
RESULTThe sequence result indicated that PCR amplified fragment was a part of HHV-7 gene, the ferritin concentration viried with the load of HHV-7.
CONCLUSIONThe occurrence of hemophagocytic syndrome is connetted with the load of HHV-7.
