The early diagnosis value of EV 71 IgM class antibodies in the hand, foot and mouth disease

VernacularTitle:肠道病毒71型IgM抗体检测在手足口病早期诊断中的价值
Author: Jing ZHAO ¹ ; Jun XU ; Wei-Wei CHEN ; Yong-Li LI ; Yan TANG ; Jia LI ; Hai-Bin WANG ; Tong-Sheng GUO ; Min ZHAO ; Bo-An LI ; Yuan-Li MAO
Author Information

1. 解放军第302医院
Keywords: Hand,foot and mouth disease; Enterovirus; Immumogloblin M; Diagnosis,differential
From: Chinese Journal of Experimental and Clinical Virology 2011;25(2):140-142
CountryChina
Language:Chinese
Abstract: Objective Assessment of detection of IgM antibodies for human enterovirus 71 ( EV 71 ) in early diagnosis for the hand, foot and mouth disease (HFMD). Method The sera and throat swabs from 38 patients which were clinical diagnosis as HFMD, were continuous daily collected in our hospital in 2010.These specimens were detected by EV 71 IgM antibodies assay, real time RT-PCR methods for EV 71 and Enterovirus. Results Among 38 HFMD patients, the cumulative positive rates of EV 71 IgM antibodies were: 60.5% on day 1,71.1% on day 2, 81.5% in the first 3-4 days, 92. 1% on day 5, 92. 1% on day 6, and the positive rate of nucleic acid detected by the real time RT-PCR for EV 71 and Enterovirus were 60. 5%, 73.6%. Conclusion The positive rate of EV 71 IgM antibodies in the hand, foot and mouth disease just can occur on day 1 ,and reach to peak on day 5 ,which can be used as one of indicators of early diagnosis of hand, foot and mouth disease.