Analysis of drug-resistant multi-loci mutaion of P area of HBV genome in 32 patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2011.03.016
- VernacularTitle:32例慢性乙型肝炎患者HBV P区的多位点耐药突变分析
- Author:
Fei YE
1
;
Xiao-Ou LI
;
Jian-Chun GUO
;
Jing WU
Author Information
1. 浙江大学医学院
- Keywords:
Hepatitis B virus;
Drug tolerance;
Mutation
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(3):208-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to deeply understand the effects of nucleoside analogues to HBV DNA polymerase area, which initiate a state of drug resistance due to HBV genome mutation. Methods Using PCR product direct sequencing method to test the gene sequence of P area of HBV genome of the patients who taking nucleoside analogues and showing signs of virologic breakthrough. Results More resistance mutations can be find in HBV DNA polymerase area,which causing clinically cross drug resistance and multiple resistance. Conclusion We should choose higher genetic barrier for the initial treatment. And the patients long-term using of nucleoside analogues, should be regularly monitored serum HBV DNA level, in order for early detection of virological breakthrough and timely intervention.
