Relationship between viral genotype and specific and nonspecific CTL of patients with cirrhotic hepatitis B and its significance.
- Author:
Xi-Bing GU
1
;
Xiao-Juan YANG
;
Juan-Hua WANG
;
Zhong HUA
;
Zhong-Hua LU
;
Yue-Qin XU
;
Zhi-Yuan JIA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; DNA, Viral; genetics; Female; Flow Cytometry; Genotype; Hepatitis B; genetics; immunology; Humans; Liver Cirrhosis; immunology; virology; Male; Middle Aged; T-Lymphocytes, Cytotoxic; immunology
- From: Chinese Journal of Experimental and Clinical Virology 2011;25(3):211-213
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore relationship between different HBV genotypes and peripheral blood HBV specific and nonspecific CTL of patients with cirrhotic hepatitis B and its significance.
METHODSHBV genotypes were tested in 91 patients with cirrhotic hepatitis B, differences of HBV specific and nonspecific CTL between patients infected with genotype B and C were compared and its significance was explored.
RESULTSIn 91 cases of cirrhotic hepatitis B, 55 cases (60.44%) belong to genotype C, 35 cases (38.46%) belong to genotype B, 1 case (1.1%) belongs to mixture genotype B and C. In genotype C, 27 cases (49.09%) had positive (HLA)-A2, HBV specific CTL was 0.18% +/- 0.03%. In genotype B, 18 cases (51.43%) had positive HLA-A2, HBV specific CTL was 0.38% +/- 0.04%, higher than that in genotype C, t = 5.01, P < 0.01. Nonspecific CTL: genotype C (11.87% +/- 1.50%); genotype B (11.90% +/- 1.51%), t = 0.14, P < 0.05. HBV DNA level: genotype C (6.01 +/- 0.81) log10 copy/ml, higher than that in genotype B (5.01 +/- 0.54) log10 copy/ml, t = 5.01, P < 0.01. ALT: genotype C (251.13 +/- 131.11) U/L, higher than that in genotype B (121.25 +/- 63.21) U/L, t = 3.61, P < 0.01. TBil (45.61 +/- 15.11) micromol/L, higher than that in genotype B (28.11 +/- 6.25) micromol/L, t = 3.05, P < 0.01.
CONCLUSIONCompared with patients infected with genotype B of cirrhotic hepatitis B, HBV specific CTL of patients infected with genotype C was lower, resulting in higher level of HBV DNA and more severe damage of liver function.
