The clinical research of the MGMT expression levels in glioma pations.
- Author:
Hai-cheng XIA
1
;
Zheng-quan ZHU
;
Liang LIU
;
Hai-long TIAN
;
Zhe SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Child; China; ethnology; DNA Modification Methylases; genetics; metabolism; DNA Repair Enzymes; genetics; metabolism; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioma; enzymology; ethnology; genetics; pathology; Humans; Male; Middle Aged; Tumor Suppressor Proteins; genetics; metabolism; Young Adult
- From:Chinese Journal of Experimental and Clinical Virology 2011;25(4):265-267
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between the expression of tumor O (6)-methylquanine DNA methyl-tranferase(MGMT) and pathological grade,and the influence of racial factors on tumor MGMT expression levels for glioma patients.
METHODSCompare and analysis the correlation between the pathological grade and MGMT levels and the racial factors on MGMT expression levels by the immunohistochemical staining on the tumor specimens of 33 Uygur and 61 Han.
RESULTSThe positive rate of 61 Han gliomas pations with MGMT is 45.90% and 33 cases of the Uygur is 30.30% , there's no clear correlation between the racial factors and the tumor MGMT levels. (P >0.05). Comparative the 94 patients with pathological level and tumor MGMT level, there is no clear correlation between pathologic level and MGMT pression in tumor tissues (P >0.05).
CONCLUSIONThere's no clear correlation of tumor MGMT expression and pathological levels; and there's no significant effect between racial factors and expression of glioma MGMT.
