The analysis of effect of Th1/Th2 cytokine in the different prognosis in severe influenza A ( H1N1 )patients

VernacularTitle:Th1/Th2类细胞因子在新型甲型H1N1流感重症患者不同预后转归中作用分析
Author: Yong-Hong ZHANG ¹ ; Da-Yan WANG ; Shuang WANG ; Hui-Ping YAN ; Hao WU ; Dan-Tong ZHAO ; Xin ZHANG ; Ang LI ; Zi-Kang WANG ; Yan ZHAO
Author Information

1. 首都医科大学附属北京佑安医院
Keywords: Influeza A virus; Cytokines
From: Chinese Journal of Experimental and Clinical Virology 2011;25(4):274-276
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of cytokine in the different prognosis of patients with severe influenza A ( H1N1 ) infection. Methods 28 cases with severe influenza A ( H1 N1 ) were enrolled in the study including 16 cured cases and 12 dead cases. The cytokine level in serum was detected by Luminex technology. Results The levels of IL-2, IL-12(P70) and IFN-γ in dead group was lower than cured and normal control group and the difference were significant, P ＜ 0.05, respectively. IL-4 level in the dead group was significantly lower than cured group and normal control group, P value was 0. 0310 and 0.0012, respectively. Conclusions The Th1 cytokine level in the severe 2009 epidemic H1N1 influeaze cases shows decreased trend, and the trend is more obvious in dead cases. The decrease of Th1 cytokine may be one of reasons leading to severe clinical situation and related with the bad prognosis.