Evaluation of serum interleukin-18 and interleukin-10 in patients with HIV-1 and hepatitis viruses co-infected subjects.
- Author:
Nan-ping WU
1
;
Dan LI
;
Armin BADER
;
Stefan HOXTERMANN
;
Norbert BROCKMEYER
Author Information
- Publication Type:Journal Article
- MeSH: Acquired Immunodeficiency Syndrome; complications; immunology; Adult; Female; HIV-1; Hepatitis B; complications; immunology; Hepatitis C; complications; immunology; Humans; Interleukin-10; blood; Interleukin-18; blood; Male; Middle Aged; T-Lymphocytes, Cytotoxic; immunology; Th1 Cells; immunology; Th2 Cells; immunology
- From: Journal of Zhejiang University. Medical sciences 2003;32(2):94-96
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the significance of cytokines in patients with HIV and hepatitis viruses co-infection.
METHODSSerum levels of IL-18 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). HIV-RNA levels were measured in EDTA plasma by quantitative reverse polymerase chain reaction (PCR). CD4(+) lymphocyte counts were determined by four-color Flow cytometry (FCM).
RESULTSThe levels of IL-18 were significantly higher in HIV-infected persons compared with those in controls (P<0.05). With HIV disease progression, IL-18 levels increased while Il-10 levels decreased. HCV patients showed lower levels of IL-18 and IL-10 than those of the co-infection group.
CONCLUSIONUnivariate analyses shows significant co-variables IL-10 in co-infection. Up-regulating IL-18 activity and/or down-regulating IL-10 may be a potential therapy to patients with HIV and hepatitis viruses co-infection.
