Expression of co-receptor on different T lymphocytes subpopulations after effective HAART.
- Author:
Dan LI
1
;
Nan-ping WU
;
Armin BADER
;
Stefan HOXTERMANN
;
Norbert BROCKMEYER
Author Information
- Publication Type:Journal Article
- MeSH: Acquired Immunodeficiency Syndrome; drug therapy; immunology; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; chemistry; CD8-Positive T-Lymphocytes; chemistry; HIV-1; Humans; Receptors, CCR5; blood; drug effects; Receptors, CXCR4; blood; drug effects
- From: Journal of Zhejiang University. Medical sciences 2003;32(2):97-100
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo measure CCR5 and CXCR4 chemokine receptor expression on CD4 and CD8 T cells in HIV-1 infection and to relate levels to the distribution of CD45RO memory and CD45RA-naive subsets after effective HAART.
METHODSFour-color cytofluorometry with appropriate conjugated monoclonal antibodies (mAbs) was performed to define CD45RA and CD45RO subsets of CD4 and CD8 T cells and measure the expression of CCR5, CXCR4 in blood from 43 received HAART patients and 5 non-treated HIV and 13 healthy controls.
RESULTSThe levels of CCR5 and CXCR4 on CD4 and CD8 T cells and their CD45RO/CD45RA subsets in HIV-1-infected patients had not any statistical significance than that on control subjects and effective HAART could adjust the expression on T cells.
CONCLUSIONCXCR4/CCR5 plays an important role in the progress of HIV-1 infection. The most favorable condition for treatment should be initiated before stage B.
