Influence of HGV super-infected with HIV or HCV on the virus replication.
- Author:
Chen-huai XU
1
;
Xiao-yan HUANG
;
Jian-er WO
;
Nan-ping WU
;
Armin BADER
Author Information
- Publication Type:Journal Article
- MeSH: GB virus C; HIV; physiology; HIV Infections; virology; Hepacivirus; physiology; Hepatitis C; virology; Hepatitis, Viral, Human; virology; Humans; RNA, Viral; blood; Virus Replication
- From: Journal of Zhejiang University. Medical sciences 2003;32(2):107-111
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo realize human immunodeficiency virus(HIV) and hepatitis C virus(HCV) super-infected with hepatitis G virus(HGV or GBV/C) and to probe into the mechanism of these virus infection in the body.
METHODSHIV and HCV load were tested by the quantitated RT-PCR in the HIV or HCV infected plasma samples respectively and the HGV RNA was detected in all of the samples. Then some of the HGV positive were sequenced.
RESULTS123 of 317 HIV patients were positive for HGV, the positive rate was 38.8%. Among the 91 HCV patients, 19 were positive for HGV. The positive rate is 20.9% which was less than that of HIV patients. HIV load of the patients super-infected with HGV was less than that of those without HGV[(1.8+/-0.6)x10 copies/ml compared with (1.9+/-1.1)x10(2)copies/ml]; while HGV and HCV super-infection did not influence the HCV RNA load significantly [(1.5+/-0.6)x10(4) copies/ml compared with (5.4+/-1.8)x10(4)copies/ml]. The HGV sequences from HIV or HCV patients were compared and showed no difference markedly.
CONCLUSIONThe rate of the HIV and HGV super-infection is higher than that of HCV. HGV may inhibit HIV reproduction in the body while superinfection.
