Effects of atenolol and diltiazem-SR on quality of life in the hypertensive patients.
- Author:
Xue-yan YAO
1
;
Wei-hu FAN
;
Jun-zhu CHEN
;
Jian-hua ZHU
;
Bao-xian CHEN
;
Xiao-jian LIU
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Aged; Atenolol; adverse effects; therapeutic use; Blood Pressure; drug effects; Diltiazem; adverse effects; therapeutic use; Female; Heart Rate; drug effects; Humans; Hypertension; drug therapy; psychology; Male; Middle Aged; Quality of Life
- From: Journal of Zhejiang University. Medical sciences 2003;32(3):231-234
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the efficacy of atenolol and diltiazem-SR and the effects on the quality of life in hypertensive patients.
METHODSSeventy-three patients with mild to moderate hypertension (DBP 90 - 109 mmHg) were allocated randomly to be administered with atenolol 25 mg/d (group A, n=37) and diltiazem-SR 90 mg/d (group B, n=36) for eight weeks. The changes of heart rate, office blood pressure(OBP), ambulatory blood pressure(ABP) and the quality of life were compared before and after treatment.
RESULTSHeart rate, OBP and ABP decreased after treatment in both groups. The effective rate of blood pressure was 88.2% in group A and 93.8% in group B. Twenty four hour mean daytime and nighttime BP,daytime and nighttime BP loads declined in both groups (P<0.05 - 0.01). The quality of life was significantly increased in group B (P<0.05). Side effects were 21.6% in group A and 11.1% in group B, respectively (P>0.05).
CONCLUSIONAtenolol and diltiazem-SR are more effective and tolerant in the treatment of the hypertension. Diltiazem improves the quality of life better than atenolol.
