Effects of EGF/EGFR expression on atrophic gastritis in rats.

Author: Qian CAO ¹ ; Jian-min SI ; Jia-guo WU
Author Information

1. The Sir Run Run Shaw Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310016, China.
Publication Type:Journal Article
MeSH: Animals; Epidermal Growth Factor; blood; physiology; Gastric Mucosa; chemistry; Gastritis, Atrophic; drug therapy; metabolism; Male; Rats; Rats, Sprague-Dawley; Receptor, Epidermal Growth Factor; analysis; physiology
From: Journal of Zhejiang University. Medical sciences 2003;32(3):235-236
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the epidermal growth factor(EGF) and epidermal growth factor receptor(EGFR) expression in atrophic gastritis in rats to explore the relationship between EGF and chronic atrophic gastritis(CAG).
METHODSThe serum EGF and gastric mucosal, EGFR level were measured in 20 rats with CAG and 20 normal controls.
RESULTSThe average EGF level (0.149+/-0.020) microg/L and 80% positive rate of EGFR expression observed in CAG group were significantly higher than those in control group[(0.043+/-0.003) microg/L and 0%,P<0.01].
CONCLUSIONThe study demonstrates an association of high levels of EGF and positive EGFR expression in CAG rats. Further studies are necessary to clarify whether EGF/EGFR play a significant role in the pathogenesis of CAG.