Comparison of RR-formoterol with rac-formoterol in bronchodilating effect on human bronchus.
- Author:
Ji-de XU
1
;
Qiang-min XIE
;
Ji-qiang CHEN
;
Ru-lian BIAN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Bronchi; drug effects; physiology; Bronchodilator Agents; pharmacology; Carbachol; pharmacology; Dose-Response Relationship, Drug; Ethanolamines; pharmacology; Formoterol Fumarate; Histamine; pharmacology; Humans; In Vitro Techniques; Middle Aged; Stereoisomerism
- From: Journal of Zhejiang University. Medical sciences 2003;32(4):300-303
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the bronchodilating effect of RR-formoterol (RR-FMT) with that of racemic formoterol (rac-FMT) on human bronchus.
METHODSHuman bronchial spiral strips (2 - 4 mm internal diameter,15 mm length) were suspended in tissue baths under resting tension of 1.0 g. The changes of tension induced by RR-FMT and rac-FMT(10 pmol x L(-1) - 3.2 micromol x L(-1)) in a cumulative concentration manner were studied under resting tension conditions or precontraction with carbamylcholine (10 micromol x L(-1)) or histamine(100 micromol x L(-1)) in human bronchus.
RESULTThe bronchodilating effect of RR-FMT was more potent than that of rac-FMT under resting condition(P<0.05). RR-FMT and rac-FMT reversed histamine or carbamylcholine-induced contraction, and the bronchodilating effect of RR-FMT was more potent than that of rac-FMT (P<0.05).
CONCLUSIONThe bronchodilating effect of RR-FMT is more potent than that of rac-FMT in both the resting condition and carbamylcholine or histamine-induced contraction in human bronchus in vitro.
