Expression of vascular cell adhesion molecule-1 in lung slices from antigen sensitized rats and pharmacological modulation.
- Author:
Xiao-hong YANG
1
;
Er-qing WEI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chromones; pharmacology; Dexamethasone; pharmacology; Female; In Vitro Techniques; Lung; chemistry; Male; Ovalbumin; immunology; Piperidines; pharmacology; Quinuclidines; pharmacology; Rats; Rats, Sprague-Dawley; Vascular Cell Adhesion Molecule-1; analysis
- From: Journal of Zhejiang University. Medical sciences 2003;32(4):319-322
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of vascular cell adhesion molecule-1(VCAM-1) in lung slices from antigen -sensitized rats and the modulation by drugs.
METHODSIn isolated lung slices from ovalbumin(OVA)-sensitized rats, the relative expression of VCAM-1 was determined after drug treatment and OVA challenge.
RESULTThe expression of VCAM-1 was enhanced in the sensitized rat lungs,and OVA challenge did not further increase the expression. Glycocorticosteroid dexamethasone and leukotriene cysLT receptor antagonist ONO-1078 inhibited the expression,but tachykinin NK-1 receptor antagonist SR-140333 had no such effect.
CONCLUSIONVCAM-1 expression is enhanced in the sensitized rat lungs, and antigen challenge does not further up regulate the expression. Anti-inflammatory drugs have different effects on VCAM-1 expression. Dexamethasone and ONO-1078, but not SR-140333, can inhibit the expression.
