Study of levels of IL-18 and IFN-Gamma in serum of patients with condyloma acuminatum.
- Author:
Guo-ying LIU
1
;
Hang-ping YAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Condylomata Acuminata; immunology; Female; Humans; Interferon-gamma; blood; Interleukin-18; blood; Male; Middle Aged
- From: Journal of Zhejiang University. Medical sciences 2003;32(4):327-329
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the role of interleukin(IL)18 and interferon gamma (IFN-Gamma) in the pathogenesis of condyloma acuminatum(CA).
METHODSDouble antibody sandwich ELISA was used to measure the levels of IL-18 and IFN-Gamma in serum of 30 cases of CA.
RESULTThe serum levels of IL-18 and IFN-Gamma of the CA patients were significantly higher than those of normal controls IL-18 132.00 +/-52.92 microg/L compared with 50.79 +/- 23.48 microg/L, P<0.01 IFN-Gamma:80.83 +/-20.46 microg/L compared with 20.71 +/-11.18 microg/L P <0.01) and IL-18 levels were positively correlated with IFN-Gamma concentrations (r=0.754, t=6.081, P <0.01).
CONCLUSIONThese data suggest that during infection of human papilloma viruses, anti-infective immune responses are activated.
