Distribution of lamivudine- resistant variants in hepatitis B virus.
- Author:
Guan-guan SU
1
;
Dan-hong YANG
;
Nian-feng ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Antiviral Agents; pharmacology; Drug Resistance, Viral; Genetic Variation; Hepatitis B virus; drug effects; genetics; Lamivudine; pharmacology
- From: Journal of Zhejiang University. Medical sciences 2003;32(4):349-358
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the distribution of HBV variants resistant to lamivudine and their relation to clinical manifestations of chronic hepatitis.
METHODSUsing direct sequencing, YMDD (tyrosine-methionine-aspartate-aspartate) variants in patients with chronic HBV were detected before and during treatment with lamivudine. A statistical analysis of the distribution of HBV strains resistant to lamivudine was performed.
RESULTFour variant strains existed in patients before lamivudine treatment, 128 variant resistant strains were noted after 6 mouths of lamivudine treatment including 42 YVDD (valine) variants, 20 YIDD (isoleusine) variants and 66 non-YMDD variants. According to the hepatitis severity, 8 patients were mild, 108 moderate and 12 severe. Viral loading was higher and clinical types were more severe in no-YMDD variants.
CONCLUSIONVariant strains including strains resistant to lamivudine exist naturally before lamivudine treatment, but lamivudine-resistant ones become more dominant after treatment. Liver inflammation is more severe in non-YMDD group.
