Improved method of epalrestat synthesis.
- Author:
Rong SHENG
1
;
Tao LIU
;
Yong-zhou HU
Author Information
- Publication Type:Journal Article
- MeSH: Aldehyde Reductase; antagonists & inhibitors; Enzyme Inhibitors; chemical synthesis; Rhodanine; analogs & derivatives; chemical synthesis; Thiazolidines
- From: Journal of Zhejiang University. Medical sciences 2003;32(4):356-358
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo synthesize epalrestat and to improve the method of synthesis.
METHODSGlycine reacted with carbondisulfide,then with ClCH(2)COONa to give 3-carboxymethylrhodanine. PhCHO reacted with CH(3)CH(2)CHO in NaOH/EtOH solution to produce 2-methylcinnamaldehyde.3-carboxymethylrhodanine and 2-methylcinnamaldehyde were treated with NH(3).H(2)O to obtain epalrestat.
RESULTThe described method was effective in synthesis of Epalrestat and the yield was higher than that of in references.
CONCLUSIONThe results suggest that this method is suitable for industrial production.
