G894T mutation of the endothelial nitric oxide synthase gene in Chinese Han nationality.
- Author:
Dan-hong WEI
1
;
Wei LI
;
Ying-hong HU
;
Zhi-mei CHEN
;
Jiang SHAN
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; China; ethnology; Genotype; Humans; Mutation; Nitric Oxide Synthase; genetics; Nitric Oxide Synthase Type III; Polymerase Chain Reaction
- From: Journal of Zhejiang University. Medical sciences 2003;32(5):415-426
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of G894T mutation of the endothelial nitric oxide synthase (eNOS) gene in Chinese Han nationality.
METHODSG894T mutation of the eNOS gene of 108 unrelated healthy individuals was studied by means of polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) analysis.
RESULTAll subjects were genotyped for eNOS gene; the frequencies of the GG, GT and TT genotypes were 0.9095, 0.0883 and 0.0021, respectively. In the Han nationality, the frequency of the GT, TT genotypes was lower than that in Japanese and Caucasian of UK (P< 0.05).
CONCLUSIONThese results suggest that there are significant differences in G894T mutation of eNOS gene between the Chinese Han nationality and other ethnic populations.
