Chemical constituents from ripe fruit of Cornus officinalis.
- Author:
Xian-Sheng YE
1
;
Jun HE
2
;
Jia-Lin ZHANG
3
;
Xiao-Bin PANG
3
;
Lei ZHANG
4
;
Hao-Yi QIAO
5
;
Xue-Ge PAN
5
;
Jia ZHANG
1
;
Shu-Na LIU
1
;
Wei-Ku ZHANG
6
;
Jie-Kun XU
5
Author Information
- Publication Type:Journal Article
- Keywords: 6′-O-acetyl-7α-O-ethyl morroniside; Cornus officinalis; PC12 cells; chemical constituents
- From: China Journal of Chinese Materia Medica 2016;41(24):4605-4609
- CountryChina
- Language:Chinese
- Abstract: To investigate the chemical compounds from the fruit of Cornus officinalis, six compounds were isolated and determined by extensive spectroscopic analysis as 6'-O-acetyl-7α-O-ethyl morroniside (1), (-)-isolariciresinol 3α-O-β-D-glucopyranoside(2), apigenin (3), cirsiumaldehyde(4), p-coumaric acid (5), caffeic acid (6). Compound 1 was a new iridoid glucoside,and compounds 2-4 were obtained from the Cornus genus for the first time. Compounds 2-6 were evaluated for the viability of PC12 cells when exposed in conditions of oxygen and glucose deprivation. The MTT results showed that compound 4 increased cell viability moderately in OGD/R treated PC12 cells at the concentration of 1.0 μmol•L⁻¹.
