Study on chemical constituents of Codonopsis pilosula.
10.19540/j.cnki.cjcmm.20161222.046
- Author:
Ya-Jing FENG
1
;
Xiao-Xia WANG
2
;
Peng-Yu ZHUANG
2
;
Dan-Yang ZHANG
2
;
Lei GAO
2
;
Jin-Ming CHEN
2
;
Gang HAN
2
Author Information
1. School of Public Health, North China University of Science and Technology, Tangshan 063000, China.
2. College of Pharmacy, North China University of Science and Technology, Tangshan 063000, China.
- Publication Type:Journal Article
- Keywords:
Campanulaceae;
Codonopsis pilosula;
chemical constituent;
neolignan
- From:
China Journal of Chinese Materia Medica
2017;42(1):135-139
- CountryChina
- Language:Chinese
-
Abstract:
A new neolignan, (-)-(7R,8S,7'E)-3',4-dihydroxy-3-methoxy-8,4'-oxyneoligna-7'-ene-7,9,9'-triol(1), and seven known compounds, 9-(tetrahydropyran-2-yl)-nona-trans,trans-2,8-diene-4,6-diyn-1-ol (2), 9-(tetrahydropyran-2-yl)-trans-non-8-ene-4,6-diyn-1-ol (3), lobetyol (4), lobetyolin (5),dehydrodieoniferyl alcohol (6), 5-hydroxymethylfurfural (7), and 4, 4'-dihydroxy-3, 3'-dimethoxy-trans-stilbene (8), were isolated from the H2O extract of Codonopsis pilosula. The structures of 1-8 were elucidated by spectroscopic methods including NMR, HR-ESI-MS, and CD. In addition, compounds 2 and 3 were isolated from the genus Codonopsis for the first time.
