A new cytotoxic alkaloid from roots of Alangium chinense.
- Author:
Huan-Huan XING
1
;
Kun ZHOU
1
;
Yan YANG
1
;
Ling ZHOU
1
;
Wei DONG
1
;
Yue-de WANG
1
;
Hang-Ying MA
1
;
Min ZHOU
1
;
Yan-Qing YE
1
;
Qiu-Fen HU
1
Author Information
- Publication Type:Journal Article
- Keywords: Alangium chinense; alkaloid; cytotoxicity
- From: China Journal of Chinese Materia Medica 2017;42(2):303-306
- CountryChina
- Language:Chinese
- Abstract: We have carried out the chemical investigation on the roots of Alangium chinense. The chemical constituents from the roots of A.chinense were isolated and purified by various chromatographic techniques, such as silica gel, MCI-Gel resin, Sephadex LH-20 and high performance liquid chromatography. As a result, three alkaloids (1-3) were isolated from 90% EtOH extracts of the roots of this plant. Their structures were elucidated by physical-chemical properties and spectral data. Among them, compound 1 is a new compound, determined as 8-hydroxy-3-hydroxymethyl-6,9-dimethyl-7H-benzo[de]isoquinolin-7-one. Cytotoxicity of the compounds was evaluated by the MTT method. Compound 1 displayed cytotoxicity against NB4, A-549, SHSY5Y, PC-3 and MCF-7 cell lines with IC₅₀ values of 4.2, 3.5, 5.7, 2.8 and 3.9 μmol•L⁻¹, respectively.
