Studies on alkaloids from Melodinus moraei.
10.19540/j.cnki.cjcmm.20161222.006
- Author:
Yan LU
1
;
Nai-Tao SHEN
1
;
He-Yong YU
1
Author Information
1. The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu 322000, China.
- Publication Type:Journal Article
- Keywords:
Melodinus;
Melodinus moraei;
alkaloids;
antitumor activity
- From:
China Journal of Chinese Materia Medica
2017;42(2):307-310
- CountryChina
- Language:Chinese
-
Abstract:
To study the alkaloids from Melodinus moraei,seven compounds were separated and purified by column chromatography over silica gel, reverse phase silica gel and preparative HPLC. Their chemical structures were elucidated by MS and spectral data (1H-NMR, 13C-NMR) as scandine(1),tabersonine(2),melodinine N(3),melodinine P(4), melodinine T(5),19-epimeloscandonine(6),16-hydroxy-19S-vindolinine(7). Compounds 1-7 were isolated from M. moraei for the first time．The bioassays showed all tested samples displayed antitumor activity against the cell lines such as A549,PC-3,HGC-27 and HL-60.
