Characteristics of supramolecular imprinting template on liver meridian tropism of traditional Chinese medicine based on molecular connectivity index.
10.19540/j.cnki.cjcmm.20161222.015
- Author:
Shi-Qi FAN
1
;
Sen LI
1
;
Jin-Ling LIU
1
;
Jiao YANG
1
;
Chao HU
1
;
Jun-Ping ZHU
1
;
Xiao-Qin XIAO
1
;
Wen-Long LIU
1
;
Fu-Yuan HE
1
Author Information
1. School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, China.
- Publication Type:Journal Article
- Keywords:
ingredients of traditional Chinese medicine;
liver meridian;
molecular connectivity index;
supramolecular imprinting template
- From:
China Journal of Chinese Materia Medica
2017;42(2):390-395
- CountryChina
- Language:Chinese
-
Abstract:
The molecular connectivity index was adopted to explore the characteristics of supramolecular imprinting template of herbs distributed to liver meridian, in order to provide scientific basis for traditional Chinese medicines(TCMs) distributed to liver meridian. In this paper, with "12th five-year plan" national planning textbooks Science of Traditional Chinese Medicine and Chemistry of Traditional Chinese Medicine as the blueprint, literatures and TCMSP sub-databases in TCM pharmacology of northwest science and technology university of agriculture and forestry were retrieved to collect and summarize active constituents of TCM distributed to liver meridian, and calculate the molecular connectivity index. The average molecular connectivity index of ingredients distributed to liver meridian was 9.47, which was close to flavonoid glycosides' (9.17±2.11) and terpenes (9.30±3.62). Therefore, it is inferred that template molecule of liver meridian is similar to physicochemical property of flavonoid glycosides and terpenes, which could be best matched with imprinting template of liver meridian.
