Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study.
- Author:
Chen-Hong WANG
1
;
Li-Zhong DU
1
;
Xiao-Lu MA
1
;
Li-Ping SHI
1
;
Xiao-Mei TONG
2
;
Hong LIU
3
;
Guo-Fang DING
4
;
Bin YI
5
;
Xin-Nian PAN
6
;
Dan-Ni ZHONG
7
;
Ling LIU
8
;
Mei LI
9
;
Cui-Qing LIU
10
;
Shi-Wen XIA
11
;
Hong-Yun WANG
12
;
Ling HE
13
;
Kun LIANG
14
;
Xiao-Yu ZHOU
15
;
Shu-Ping HAN
16
;
Qin LYU
17
;
Yin-Ping QIU
18
;
Ruo-Bing SHAN
19
;
De-Zhi MU
20
;
Xiao-Hong LIU
21
;
Si-Qi ZHUANG
22
;
Jing GUO
23
;
Li LIU
24
;
Jia-Jun ZHU
25
;
Hong XIONG
26
Author Information
- Publication Type:Journal Article
- MeSH: Cause of Death; China; Female; Hospital Mortality; Humans; Infant; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; mortality; Intensive Care Units, Neonatal; statistics & numerical data; Male; Perinatal Death; Retrospective Studies
- From: Chinese Medical Journal 2016;129(22):2652-2658
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDGlobally, the proportion of child deaths that occur in the neonatal period remains a high level of 37-41%. Differences of cause in neonate death exist in different regions as well as in different economic development countries. The specific aim of this study was to investigate the causes, characteristics, and differences of death in neonates during hospitalization in the tertiary Neonatal Intensive Care Unit (NICU) of China.
METHODSAll the dead neonates admitted to 26 NICUs were included between January l, 2011, and December 31, 2011. All the data were collected retrospectively from clinical records by a designed questionnaire. Data collected from each NICU were delivered to the leading institution where the results were analyzed.
RESULTSA total of 744 newborns died during the 1-year survey, accounting for 1.2% of all the neonates admitted to 26 NICUs and 37.6% of all the deaths in children under 5 years of age in these hospitals. Preterm neonate death accounted for 59.3% of all the death. The leading causes of death in preterm and term infants were pulmonary disease and infection, respectively. In early neonate period, pulmonary diseases (56.5%) occupied the largest proportion of preterm deaths while infection (27%) and neurologic diseases (22%) were the two main causes of term deaths. In late neonate period, infection was the leading cause of both preterm and term neonate deaths. About two-thirds of neonate death occurred after medical care withdrawal. Of the cases who might survive if receiving continuing treatment, parents' concern about the long-term outcomes was the main reason of medical care withdrawal.
CONCLUSIONSNeonate death still accounts for a high proportion of all the deaths in children under 5 years of age. Our study showed the majority of neonate death occurred in preterm infants. Cause of death varied with the age of death and gestational age. Accurate and prompt evaluation of the long-term outcomes should be carried out to guide the critical decision.