A study of CXCR4/SDF-1 in hepatocellular carcinoma and liver cirrhosis.
- Author:
Guo-ying SHI
1
;
De-jin SHI
;
Wei-biao LÜ
;
Yong-kun CHEN
;
Xiang-min TONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Carcinoma, Hepatocellular; metabolism; pathology; Case-Control Studies; Chemokine CXCL12; metabolism; Humans; Liver Cirrhosis; metabolism; pathology; Neoplasm Staging; Receptors, CXCR4; metabolism
- From: Chinese Journal of Hepatology 2007;15(4):276-278
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of stromal cell-derived factor-1 (SDF-1) and CX chemokine receptor-4 (CXCR-4) in patients with hepatocellular carcinoma (HC) and liver cirrhosis.
METHODSPeripheral blood and/or ascites fluid were collected from 39 hepatocellular carcinoma patients, 16 patients with liver cirrhosis, 12 with hepatitis and 12 healthy donors. The SDF-1 expression was assayed by ELISA and CXCR-4 was measured by immunohistochemical methods.
RESULTSThe level of SDF-1 expression in the carcinoma patients was higher than that of the liver cirrhosis, hepatitis patients and healthy donors, but there was no significant difference between those of the healthy donors and hepatitis patients or liver cirrhosis patients. The levels of CXCR-4 expression were closely related to the tumor differentiation.
CONCLUSIONThe expression of SDF-1 in the peripheral blood and the CXCR4 expression in the HCC tissues of the HC patients may be regarded as markers of HC and they may have a positive relationship with the differentiation and metastasis of HC.
