The presence and the significance of CD4+CD25+ regulatory T cells in livers of patients with hepatocellular carcinoma.
- Author:
Xiu-hua YANG
1
;
Bing-rong LIU
;
Hong-chi JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Carcinoma, Hepatocellular; immunology; pathology; Case-Control Studies; Female; Flow Cytometry; Humans; Interleukin-2 Receptor alpha Subunit; immunology; Liver Neoplasms; immunology; pathology; Male; Middle Aged; T-Lymphocytes, Regulatory; immunology; Young Adult
- From: Chinese Journal of Hepatology 2007;15(4):279-282
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the presence and clinical significance of CD4+CD25+ regulatory T cells in liver tissues of hepatocellular carcinoma (HCC) patients.
METHODSCD4+CD25+ regulatory T cells and CD8+ cells and their relative proportions in liver tissues and peripheral blood of HCC patients and of healthy volunteers were analyzed using flow cytometry. The distributions of CD4+CD25+ regulatory T cells in liver tissues were also analyzed.
RESULTSAround the tumor tissues (peri-tumor), the percentage of CD4+CD25+ regulatory T cells was 10.8% +/- 2.3%, which was obviously higher than in the tissues away from the cancer tissues (P < 0.05). The percentage of CD4+CD25+ regulatory T cells in the peripheral blood of HCC patients was 9.4% +/- 1.0%, which was obviously lower than that of the healthy volunteers (12.9% +/- 1.3%) (P < 0.01). With increasing CD4+CD25+ regulatory T cells in the peri-tumor tissue, there was a trend of CD8+ cells decreasing.
CONCLUSIONCD4+CD25+ regulatory T cells played an anti-tumor immunity role in hepatocellular carcinoma by restraining the CD8+ cells.
